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Zelnorm is generally recommended for treating women having IBS with constipation as the primary bowel symptom. It may be used for managing chronic idiopathic constipation in people under 65.

The common dose is six mg two times a day generally for four - twelve weeks.

Zelnorm is in a group of oral medicines for treating constipation as well as constipation predominant irritable bowel syndrome in females. IBS represents a chronic gastrointestinal disease accompanied with discomfort and abdominal pain, altered bowel function (either diarrhea or constipation). 20% of adults suffer from IBS symptoms in the USA. Intestinal muscles contractions control food movement in the intestine. In people with constipation, fewer contractions occur. Serotonin is responsible for controlling contractions. Actually serotonin is a substance produced by nerves in our intestine. It travels to the receptors near the nerves. Serotonin is a kind of chemical messenger which the nerves use for communication. When serotonin binds to nerves receptors controlling intestinal muscles contractions, it can either prevent or stimulate contractions dependant on the receptor type it is bound to. When it binds to some receptors, this evolves contractions. In case it binds to other receptors, this can block contractions. Serotonin 5-HT4 receptor prevents contractions. Zelnorm is intended to block 5-HT4 receptor thus not allowing serotonin to bind to it. This increases contractions speeding digesting food transmission. Besides, Zelnorm lowers sensitivity of pain sensing nerves in the intestine thereby decreasing pain perception.

If you forget to take a dose of the drug, skip this dosage and take your regular one. You cannot take two doses at a time.

Zelnorm should be kept at room temperature, which is about 15-30 degrees C.

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