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Propulsid increases the speed at which the esophagus, intestines and stomach move while digestive process. The drug also speeds up the rate at which the stomach empties into the intestines and enhances the strength of lower esophageal sphincter.

Propulsid is effective in managing gastric reflux, which people very often experience as heartburn. For other conditions the medicine may be taken if recommended by the doctor.

You are not to take cisapride if you suffer from a heart disorder or arteries hardenening; heart failure; an irregular heartbeat; if you have prolonged QT intervals; a family history of congenital long QT syndrome; a slow heart rate; a structural heart defect; heart block or other conduction disorders; serious dehydration, vomiting, malnutrition, an eating disorder; or kidney failure.

Propulsid cannot be combined with a number of drugs.
These are:
antibiotics such as erythromycin (Ery-Tab, E.E.S., E-Mycin)clarithromycin (Biaxin), troleandomycin, or sparfloxacin (Zagam);
antidepressants such as maprotiline (Ludiomil), amitriptyline (Elavil), and nefazodone (Serzone);
antifungal medications, among them fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral);
antihistamines like astemizole (Hismanal);
blood pressure drugs such as bepridil (Vascor);
heart medicines such as procainamide (Procan SR, Procanbid, Pronestyl) and quinidine (Quinidex, Quinaglute);
phenothiazines like prochlorperazine (Compazine, others) and promethazine (Phenergan, others);
and HIV treatments such as ritonavir (Norvir) or indinavir (Crixivan).

Before you start using any other drug check with the doctor. Do not drink alcohol because together with cisapride it adds to drowsiness. Benzodiazepines like alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), and temazepam (Restoril) also increase dizziness caused by cisapride. You are to avoid grapefruit or grapefruit juice as these products increase the amount of cisapride in the body. And this can result in severe side effects.

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